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Article

Reconstituted ferredoxin-MEP pathway of Apicomplexa in Escherichiacoli as an in situ screening platform for inhibitors and essential enzyme mutations.

The Journal of biological chemistry - 1 Nov 2025

Akuh Ojo-Ajogu, Maus Deborah, Blume Martin, Saliba Kevin J, Seeber Frank

Abstract excerpt

The apicoplast, an essential plastid-like organelle of apicomplexan parasites, including Plasmodium spp. and Toxoplasma gondii, harbors unique metabolic pathways absent in the host. Within the apicoplast, the ferredoxin redox system consists of plant-type ferredoxin-NADP+ reductase (ptFNR) and its redox partner, plant-type ferredoxin (ptFd). It donates electrons to the last two enzymes in the essential...

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Identifiers

PMID: 40967433
DOI: 10.1016/j.jbc.2025.110726
PMCID: PMC12605070

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