Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages

9 Apr 2019

Abstract excerpt

The battle against malaria has been substantially impeded by the recurrence of drug resistance in Plasmodium falciparum, the deadliest human malaria parasite. To counter the problem, novel antimalarial drugs are urgently needed, especially those that target unique pathways of the parasite, since they are less likely to have side effects. The mitochondrial type II NADH dehydrogenase (NDH2) of P. falciparum, PfNDH2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug-Induced Hepatotoxicity and Protection
Share to Malaria Research and Control
Share to Metabolism and Genetic Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30964863
DOI: 10.1371/journal.pone.0214023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stagesPMID 30964863Read ↗

Mitochondrial type II NADH dehydrogenase of <i>Plasmodium falciparum</i> is dispensable and not the functional target of putative NDH2 quinolone inhibitorsSemantic proximity Read ↗

Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors.Semantic proximity Read ↗

Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes <i>Cryptosporidium</i> to clofazimine resistanceSemantic proximity Read ↗

'Tethering' fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase.Semantic proximity Read ↗

Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I.Semantic proximity Read ↗

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility.Semantic proximity Read ↗

Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functionsSemantic proximity Read ↗

Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancerSemantic proximity Read ↗

Function of the alternative electron transport chain in the <i>Cryptosporidium parvum</i> mitosomeSemantic proximity Read ↗

Driving antimalarial design through understanding of target mechanism.Semantic proximity Read ↗

Toward understanding the role of mitochondrial complex II in the intraerythrocytic stages of Plasmodium falciparum: gene targeting of the Fp subunit.Semantic proximity Read ↗

Plasmodium falciparum Mitochondrial Complex III, the Target of Atovaquone, Is Essential for Progression to the Transmissible Sexual StagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.