Article

ApoE4 attenuates cortical neuronal activity and impairs memory in young apoE4 rats

2021-01-14

Abstract excerpt

The E4 allele of apolipoprotein E (apoE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). However, apoE4 may cause innate brain abnormalities before the appearance of AD related neuropathology. Understanding these primary dysfunctions is vital for early detection of AD and the development of therapeutic strategies for it. Recently we have shown impaired extra-hippocampal memory in you...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf0e82bc-9249-5cc5-8100-04743cbb7c10
DOI: 10.1101/2021.01.14.426651

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ApoE4 attenuates cortical neuronal activity and impairs memory in young apoE4 ratsDOI 10.1101/2021.01.14.426651Read

Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice.Semantic proximity Read

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathologySemantic proximity Read

Association of APOE ε4 Status With Long-term Declines in Odor Sensitivity, Odor Identification, and Cognition in Older US Adults.Semantic proximity Read

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease PathogenesisSemantic proximity Read

APOE4 and doxorubicin impair inhibitory interneuron function and homeostatic regulation in the entorhinal cortex.Semantic proximity Read

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimer’s Disease Risk in Humanized APOE MiceSemantic proximity Read

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.Semantic proximity Read

Structural and Synaptic Dysregulation Drives Network Vulnerability in APOE4 Human Neuronal NetworksSemantic proximity Read

Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.Semantic proximity Read

Interaction Between Odor Identification Deficit and APOE4 Predicts 6-Year Cognitive Decline in Elderly Individuals.Semantic proximity Read

Higher Neuronal Facilitation and Potentiation with APOE4 Suppressed by Angiotensin IISemantic proximity Read

Entorhinal cholecystokinin in Alzheimer’s disease: its earliest vulnerability and rescue effects across different disease stagesSemantic proximity Read