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Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease

2023-05-12

Abstract excerpt

<h4>ABSTRACT</h4> Maternal choline supplementation (MCS) improves cognition in Alzheimer’s disease (AD) models. However, effects of MCS on neuronal hyperexcitability in AD are unknown. We investigated effects of MCS in a well-established mouse model of AD with hyperexcitability, the Tg2576 mouse. The most common type of hyperexcitability in Tg2576 mice are generalized EEG spikes (interictal spikes; IIS). IIS also...

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Literature Corpus work
4e044800-ecec-50b2-9263-c76475c9eca7
DOI
10.1101/2023.05.12.540428
Open publication

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Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s diseaseDOI 10.1101/2023.05.12.540428
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