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NEURON-SPECIFIC CHROMOSOMAL MEGADOMAIN ORGANIZATION IS ADAPTIVE TO RECENT RETROTRANSPOSON EXPANSIONS

2021-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Here, we mapped cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retrovirus 2 (ERV2) repeat sequences in the neuron-specific heterochromatic ‘B 2 NeuN+ ’ megabase-scaling subcompartment. Comparative chromosomal conformation mapping in Mus spretus and Mus musculus revealed neuron-specific reconfigurations tracking recen...

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Literature Corpus work: edcb0909-6cd3-59af-8379-c93a06a15667
DOI: 10.1101/2021.08.30.458289

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