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Article

Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain

29 Jun 2017

Abstract excerpt

BACKGROUND: Moloney leukemia virus 10 (Mov10) is an RNA helicase that mediates access of the RNA-induced silencing complex to messenger RNAs (mRNAs). Until now, its role as an RNA helicase and as a regulator of retrotransposons has been characterized exclusively in cell lines. We investigated the role of Mov10 in the mouse brain by examining its expression over development and attempting to create a Mov10...

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PMID: 28662698
DOI: 10.1186/s12915-017-0387-1

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