Article

Integrative analysis of transcriptional activity and genome architecture changes upon viral infections

2018-01-01

Abstract excerpt

To study the interplay between spatial nuclear architecture and transcriptional activity during viral infections, I employed a genome-wide chromosome conformation capture approach (Hi-C) on infected murine and human cells and further enriched those libraries for genomic loci of interest and the viral genomes with biotinylated RNA baits. In parallel, I profiled newly transcribed RNA throughout the entire kinetic of...

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Literature Corpus work: 7dacc41d-af3f-5353-9bd1-7280b054542f
DOI: 10.17863/cam.22022

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