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LINE-1 retrotransposons contribute to mouse PV interneuron development

21 May 2024

Abstract excerpt

Retrotransposons are mobile DNA sequences duplicated via transcription and reverse transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons can also promote the transcription of adjacent genes. Somatic LINE-1 (L1) retrotransposon insertions have been detected in mammalian neurons. It is, however, unclear whether L1 sequences are mobile in only some neuronal lineages or therein...

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PMID: 38773348
DOI: 10.1038/s41593-024-01650-2

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