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Recent Overview of the Use of iPSCs Huntington’s Disease Modeling and Therapy

24 Mar 2020

Abstract excerpt

Huntington's disease (HD) is an inherited, autosomal dominant, degenerative disease characterized by involuntary movements, cognitive decline, and behavioral impairment ending in death. HD is caused by an expansion in the number of CAG repeats in the huntingtin gene on chromosome 4. To date, no effective therapy for preventing the onset or progression of the disease has been found, and many symptoms do not...

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PMID: 32213859
DOI: 10.3390/ijms21062239

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