Article

Human Neural Stem Cells Differentiate and Integrate, Innervating Implanted zQ175 Huntington’s Disease Mouse Striatum

2021-01-19

Abstract excerpt

Huntington’s disease (HD), a genetic neurodegenerative disorder, primarily impacts the striatum and cortex with progressive loss of medium-sized spiny neurons (MSNs) and pyramidal neurons, disrupting cortico-striatal circuitry. A promising regenerative therapeutic strategy of transplanting human neural stem cells (hNSCs) is challenged by the need for long-term functional integration. We previously described that h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd61384e-3f5d-5e54-ae74-2842fb406614
DOI: 10.1101/2021.01.18.427078

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Neural Stem Cells Differentiate and Integrate, Innervating Implanted zQ175 Huntington’s Disease Mouse StriatumDOI 10.1101/2021.01.18.427078Read

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.Semantic proximity Read

<i>In vivo</i> progressive degeneration of Huntington’s disease patient-derived neurons reveals human-specific pathological phenotypesSemantic proximity Read

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease MiceSemantic proximity Read

Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease.Semantic proximity Read

Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature ReviewSemantic proximity Read

Use of human stem cells in Huntington disease modeling and translational research.Semantic proximity Read

Recent Overview of the Use of iPSCs Huntington’s Disease Modeling and TherapySemantic proximity Read

Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturationSemantic proximity Read

Therapeutic advances in neural regeneration for Huntington's diseaseSemantic proximity Read

Concise Review: The Use of Stem Cells for Understanding and Treating Huntington's Disease.Semantic proximity Read

Reprogrammed Human Lateral Ganglionic Eminence Precursors Generate Striatal Neurons and Restore Motor Function in a Rat Model of Huntington’s DiseaseSemantic proximity Read

Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington’s Disease and Possible Therapeutic AvenuesSemantic proximity Read