Article

A mathematical model clarifies the ABC Score formula used in enhancer-gene prediction

2024-12-03

Abstract excerpt

Enhancers are discrete DNA elements that regulate the expression of eukaryotic genes. They are important not only for their regulatory function, but also as loci that are frequently associated with disease traits. Despite their significance, our conceptual understanding of how enhancers work remains limited. CRISPR-interference methods have recently provided the means to systematically screen for enhancers in cell...

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Literature Corpus work: edb65d62-a926-58d8-85c4-41e3f474882a
DOI: 10.1101/2024.11.29.626072

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