Article
Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk.
Nature communications - 25 Sept 2023
Ying Pingting, Chen Can, Lu Zequn, Chen Shuoni, Zhang Ming, Cai Yimin, Zhang Fuwei, Huang Jinyu, Fan Linyun, Ning Caibo, Li Yanmin, Wang Wenzhuo, Geng Hui, Liu Yizhuo, Tian Wen, Yang Zhiyong, Liu Jiuyang, Huang Chaoqun, Yang Xiaojun, Xu Bin, Li Heng, Zhu Xu, Li Ni, Li Bin, Wei Yongchang, Zhu Ying, Tian Jianbo, Miao Xiaoping
Abstract excerpt
Genome-wide association studies have identified numerous variants associated with human complex traits, most of which reside in the non-coding regions, but biological mechanisms remain unclear. However, assigning function to the non-coding elements is still challenging. Here we apply Activity-by-Contact (ABC) model to evaluate enhancer-gene regulation effect by integrating multi-omics data and identified 544,849...
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