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Article

Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation.

EMBO molecular medicine - 1 Jan 2010

Berta Melanie A, Baker Christopher M, Cottle Denny L, Watt Fiona M

Abstract excerpt

Myc is activated in many tumours, yet, paradoxically, stimulates differentiation in mammalian epidermis. To test whether the epidermis responds differently to different levels of Myc, we treated K14MycER transgenic mice with a range of concentrations of the inducing agent, 4-hydroxy-tamoxifen (4OHT). Proliferation was stimulated at all levels of Myc activity; sebocyte differentiation was stimulated at low and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20043278
DOI: 10.1002/emmm.200900047
PMCID: PMC2929372

Genes

PAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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