Article
Humanized c-Myc mouse.
PloS one - 1 Jan 2012
Lehmann Frank M, Feicht Samantha, Helm Florian, Maurberger Anna, Ladinig Camilla, Zimber-Strobl Ursula, Kühn Ralf, Mautner Josef, Gerbitz Armin, Bornkamm Georg W
Abstract excerpt
BACKGROUND: A given tumor is usually dependent on the oncogene that is activated in the respective tumor entity. This phenomenon called oncogene addiction provides the rationale for attempts to target oncogene products in a therapeutic manner, be it by small molecules, by small interfering RNAs (siRNA) or by antigen-specific T cells. As the proto-oncogene product is required also for the function of normal cells,...
Topics
- Animals
- Blotting, Southern
- Embryonic Stem Cells
- Flow Cytometry
- Genes, myc
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Phenotype
- Polymerase Chain Reaction