Article

Genetic risk of dementia modifies the impact of obesity on limbic white matter and spatial navigation behavior in cognitively healthy adults

2019-12-11

Abstract excerpt

A family history (FH) of dementia, APOE -ε4 genotype, and obesity are major risk factors for developing Alzheimer’s disease but their combined effects on the brain and cognition remain elusive. We tested the hypothesis that these risk factors affect apparent white matter (WM) myelin and cognition including spatial navigation and processing speed in 166 asymptomatic individuals (38-71 years). Microstructure in tem...

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Literature Corpus work: ed7e515e-496b-59c4-843f-cf4931f88a78
DOI: 10.1101/871160

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