Article
The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2025
Lorenz Anna, Sathe Aditi, Zaras Dimitrios, Yang Yisu, Durant Alaina, Kim Michael E, Gao Chenyu, Newlin Nancy R, Ramadass Karthik, Kanakaraj Praitayini, Khairi Nazirah Mohd, Li Zhiyuan, Yao Tianyuan, Huo Yuankai, Dumitrescu Logan, Shashikumar Niranjana, Pechman Kimberly R, Jackson Trevor Bryan, Workmeister Abigail W, Risacher Shannon L, Beason-Held Lori L, An Yang, Arfanakis Konstantinos, Erus Guray, Davatzikos Christos, Habes Mohamad, Wang Di, Tosun Duygu, Toga Arthur W, Thompson Paul M, Mormino Elizabeth C, Zhang Panpan, Schilling Kurt, Albert Marilyn, Kukull Walter, Biber Sarah A, Landman Bennett A, Johnson Sterling C, Bendlin Barbara, Schneider Julie, Barnes Lisa L, Bennett David A, Jefferson Angela L, Resnick Susan M, Saykin Andrew J, Hohman Timothy J, Archer Derek B
Abstract excerpt
INTRODUCTION: White matter (WM) microstructure is essential for brain function but deteriorates with age and in neurodegenerative conditions such as Alzheimer's disease (AD). Diffusion MRI, enhanced by advanced bi-tensor models accounting for free water (FW), enables in vivo quantification of WM microstructural differences. METHODS: To evaluate how AD genetic risk factors affect limbic WM microstructure - crucial...
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