Genetic risk factors underlying white matter hyperintensities and cortical atrophy.

doi:10.1038/s41467-024-53689-1

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Article

Genetic risk factors underlying white matter hyperintensities and cortical atrophy.

Nature communications - 4 Nov 2024

Patel Yash, Shin Jean, Sliz Eeva, Tang Ariana, Mishra Aniket, Xia Rui, Hofer Edith, Rajula Hema Sekhar Reddy, Wang Ruiqi, Beyer Frauke, Horn Katrin, Riedl Max, Yu Jing, Völzke Henry, Bülow Robin, Völker Uwe, Frenzel Stefan, Wittfeld Katharina, Van der Auwera Sandra, Mosley Thomas H, Bouteloup Vincent, Lambert Jean-Charles, Chêne Geneviève, Dufouil Carole, Tzourio Christophe, Mangin Jean-François, Gottesman Rebecca F, Fornage Myriam, Schmidt Reinhold, Yang Qiong, Witte Veronica, Scholz Markus, Loeffler Markus, Roshchupkin Gennady V, Ikram M Arfan, Grabe Hans J, Seshadri Sudha, Debette Stephanie, Paus Tomas, Pausova Zdenka

Abstract excerpt

White matter hyperintensities index structural abnormalities in the cerebral white matter, including axonal damage. The latter may promote atrophy of the cerebral cortex, a key feature of dementia. Here, we report a study of 51,065 individuals from 10 cohorts demonstrating that higher white matter hyperintensity volume associates with lower cortical thickness. The meta-GWAS of white matter...

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Identifiers

PMID: 39496600
DOI: 10.1038/s41467-024-53689-1
PMCID: PMC11535513

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