Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.

Nature communications - 18 Jun 2024

Zhukovsky Peter, Tio Earvin S, Coughlan Gillian, Bennett David A, Wang Yanling, Hohman Timothy J, Pizzagalli Diego A, Mulsant Benoit H, Voineskos Aristotle N, Felsky Daniel

Abstract excerpt

Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These risk factors, such as depression and vascular disease, do not affect all individuals in the same way, likely due to inter-individual differences in genetics. However, the precise nature of how genetic risk profiles interact with modifiable risk factors to affect brain health is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Depression

Share to Genome-Wide Association Study

Share to Longitudinal Studies

Share to Multifactorial Inheritance

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 38890310
DOI: 10.1038/s41467-024-49430-7
PMCID: PMC11189393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.PMID 38890310Read ↗

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE ConsortiumSemantic proximity Read ↗

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.Semantic proximity Read ↗

Genetic risk factors underlying white matter hyperintensities and cortical atrophy.Semantic proximity Read ↗

Brain Structure and Function Show Distinct Relations With Genetic Predispositions to Mental Health and Cognition.Semantic proximity Read ↗

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits.Semantic proximity Read ↗

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia.Semantic proximity Read ↗

Causal insights of modifiable cardiovascular risk factors for dementia risk - potential for efficient prevention and improved brain health.Semantic proximity Read ↗

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain agingSemantic proximity Read ↗

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.Semantic proximity Read ↗

Genetic Interplay Between White Matter Hyperintensities and Alzheimer’s Disease: A Brain-Body PerspectiveSemantic proximity Read ↗

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.Semantic proximity Read ↗

Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.