Article

SOX10 Expression Levels may be a Critical Mediator of White Matter Dysfunction in Schizophrenia

2022-06-17

Abstract excerpt

Abnormalities of brain connectivity are consistently observed in individuals with schizophrenias (SZ). Underlying these anomalies, convergent in vivo, post-mortem, and genomic evidence suggest abnormal oligodendrocyte (OL) development and function, including lower in vivo myelination in SZ. Using patient derived induced pluripotent stem cells (IPSCs), we previously observed a significant and substantial reduction...

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Literature Corpus work: ed7c370f-110f-52ca-a14a-a18411da843c
DOI: 10.1101/2022.06.14.496174

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