Article
Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.
Molecular psychiatry - 1 May 2019
de Vrij Femke M, Bouwkamp Christian G, Gunhanlar Nilhan, Shpak Guy, Lendemeijer Bas, Baghdadi Maarouf, Gopalakrishna Shreekara, Ghazvini Mehrnaz, Li Tracy M, Quadri Marialuisa, Olgiati Simone, Breedveld Guido J, Coesmans Michiel, Mientjes Edwin, de Wit Ton, Verheijen Frans W, Beverloo H Berna, Cohen Dan, Kok Rob M, Bakker P Roberto, Nijburg Aviva, Spijker Annet T, Haffmans P M Judith, Hoencamp Erik, Bergink Veerle, Vorstman Jacob A, Wu Timothy, Olde Loohuis Loes M, Amin Najaf, Langen Carolyn D, Hofman Albert, Hoogendijk Witte J, van Duijn Cornelia M, Ikram M Arfan, Vernooij Meike W, Tiemeier Henning, Uitterlinden André G, Elgersma Ype, Distel Ben, Gribnau Joost, White Tonya, Bonifati Vincenzo, Kushner Steven A
Abstract excerpt
Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however, direct etiological genetic and cellular evidence has thus far been lacking. Here, we implement a family-based approach for genetic discovery in schizophrenia combined with...
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