Article

Gene expression in patient-derived neural progenitors implicates WNT5A signaling in the etiology of schizophrenia

2017-10-26

Abstract excerpt

<h4>BACKGROUND</h4> GWAS of schizophrenia demonstrated that variations in the non-coding regions are responsible for most of common variation heritability of the disease. It is hypothesized that these risk variants alter gene expression. Thus, studying alterations in gene expression in schizophrenia may provide a direct approach to understanding the etiology of the disease. In this study we use C ultured N eura...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d59b332-4fcb-5ed3-9af5-711d71bbc0d6
DOI: 10.1101/209197

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene expression in patient-derived neural progenitors implicates WNT5A signaling in the etiology of schizophreniaDOI 10.1101/209197Read

Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia EtiologySemantic proximity Read

Gene Expression Elucidates Functional Impact of Polygenic Risk for SchizophreniaSemantic proximity Read

Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overviewSemantic proximity Read

BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoidsSemantic proximity Read

Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brainsSemantic proximity Read

Dysregulation of miRNAs Drives Premature GABAergic Maturation and Early Neurodevelopmental Defects in SchizophreniaSemantic proximity Read

Olfactory neuroepithelium-derived neural progenitor cells as a model system for investigating the molecular mechanisms of neuropsychiatric disorders.Semantic proximity Read

A schizophrenia-associated radial glia cell state perturbs early human brain developmentSemantic proximity Read

Single-cell multi-cohort dissection of the schizophrenia transcriptomeSemantic proximity Read

Mapping the Cellular Etiology of Schizophrenia and Diverse Brain PhenotypesSemantic proximity Read

Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloidsSemantic proximity Read

Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilienceSemantic proximity Read