Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.

doi:10.1073/pnas.1614412114

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Article

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2017

Ehrlich Marc, Mozafari Sabah, Glatza Michael, Starost Laura, Velychko Sergiy, Hallmann Anna-Lena, Cui Qiao-Ling, Schambach Axel, Kim Kee-Pyo, Bachelin Corinne, Marteyn Antoine, Hargus Gunnar, Johnson Radia Marie, Antel Jack, Sterneckert Jared, Zaehres Holm, Schöler Hans R, Baron-Van Evercooren Anne, Kuhlmann Tanja

Abstract excerpt

Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to understand the biology of myelin diseases and to develop treatments for such disorders. Here, we demonstrate that the induction of three transcription factors (SOX10, OLIG2, NKX6.2) in iPSC-derived neural progenitor cells is sufficient to rapidly...

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Identifiers

PMID: 28246330
DOI: 10.1073/pnas.1614412114
PMCID: PMC5358375

Genes

OLIG2
SOX10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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