Chronic Mild Stress Impairs Hippocampal Myelination through SOX6-Dependent Dysfunction of Oligodendrocyte Lineage Cells

Abstract excerpt

Chronic stress induces structural and functional changes in the brain, increasing susceptibility to major depressive disorder and other mental illnesses. Myelination deficits are a key pathological feature of stress-related disorders, yet the molecular mechanisms linking chronic stress to oligodendrocyte dysfunction remain poorly understood. Here, we used single-nucleus multiome sequencing to map gene expression a...

Topics

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• Birth, Development, and Health
• Down syndrome and intellectual disability research
• Epigenetics and DNA Methylation
• Neuroinflammation and Neurodegeneration Mechanisms
• Single-cell and spatial transcriptomics
• Stress Responses and Cortisol

Identifiers and source

Literature Corpus work

8f972a19-fb84-5be3-ac11-ee8bebfe7184

DOI

10.64898/2026.05.29.728722