Article

Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model

2022-03-31

Abstract excerpt

<title>Abstract</title> <p>Although the link of white matter to pathophysiology of schizophrenia is documented, loss of myelin is not detected in patients at the early stages of the disease, suggesting that pathological evolution of schizophrenia may occur before significant myelin loss. Disrupted-in-schizophrenia-1 (DISC1) protein is highly expressed in oligodendrocyte precursor cells (OPCs) and regulates their...

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Literature Corpus work: 58221568-a495-5c9e-a636-c56d4dd4abb4
DOI: 10.21203/rs.3.rs-1496764/v1

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