Article

Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis

2020-12-18

Abstract excerpt

<title>Abstract</title> <p>Background Both advanced glycation end products (AGEs) and AGE-mediated M1 macrophage polarization contribute to bone marrow mesenchymal stem cell (BMSC) dysfunction, leading to impaired bone regeneration in type 1 diabetes mellitus (T1DM). Adrenomedullin 2 (ADM2), an endogenous bioactive peptide belonging to the calcitonin gene-related peptide family, exhibits various biological activ...

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Literature Corpus work: ed66695c-8371-593b-b9a9-4439debe6c91
DOI: 10.21203/rs.3.rs-130211/v1

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