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Article

Insulin promotes macrophage phenotype transition through PI3K/Akt and PPAR-γ signaling during diabetic wound healing.

Journal of cellular physiology - 1 Apr 2019

Yu Tianyi, Gao Min, Yang Peilang, Liu Dan, Wang Di, Song Fei, Zhang Xiong, Liu Yan

Abstract excerpt

Overactivation and persistent chronic inflammation are the major pathogenic characteristics of diabetic-impaired healing, and diabetic wound healing can be promoted by stimulating the transition of macrophage phenotype from pro-inflammatory (M1) to anti-inflammatory (M2). Our previous studies found that the application of insulin induced an advanced initiation and resolution of inflammatory response. To further...

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PMID: 30132863
DOI: 10.1002/jcp.27185

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STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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