Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4Rα-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK.

Nutrients - 6 Jul 2020

Oh Hyeongjoo, Park Sin-Hye, Kang Min-Kyung, Kim Yun-Ho, Lee Eun-Jung, Kim Dong Yeon, Kim Soo-Il, Oh Su Yeon, Na Woojin, Lim Soon Sung, Kang Young-Hee

Abstract excerpt

Macrophage polarization has been implicated in the pathogenesis of metabolic diseases such as obesity, diabetes, and atherosclerosis. Macrophages responsiveness to polarizing signals can result in their functional phenotype shifts. This study examined whether high glucose induced the functional transition of M2 macrophages, which was inhibited by asaronic acid, one of purple perilla constituents. J774A.1 murine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzoates
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus

Share to Glucose

Share to Intracellular Signaling Peptides and Proteins

Share to Macrophage Activation

Share to Macrophages

Share to Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 32640667
DOI: 10.3390/nu12072006
PMCID: PMC7400890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4Rα-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK.PMID 32640667Read ↗

Codonopsis pilosula-derived glycopeptide dCP1 promotes the polarization of tumor-associated macrophage from M2-like to M1 phenotype.Semantic proximity Read ↗

Salvianolic acid B inhibits RAW264.7 cell polarization towards the M1 phenotype by inhibiting NF-κB and Akt/mTOR pathway activation.Semantic proximity Read ↗

Treatment with sitagliptin exacerbates the M2 phenotype in macrophages in vitro.Semantic proximity Read ↗

Pyropia yezoensis glycoprotein promotes the M1 to M2 macrophage phenotypic switch via the STAT3 and STAT6 transcription factors.Semantic proximity Read ↗

Metabolic Reprogramming of Human Macrophages Drives the Formation of Hybrid M1/M2 Pro-Regenerative Extracellular VesiclesSemantic proximity Read ↗

Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesisSemantic proximity Read ↗

Pinosylvin Shifts Macrophage Polarization to Support Resolution of Inflammation.Semantic proximity Read ↗

High glucose promotes macrophage switching to M1 phenotype via down-regulating STAT-3 mediated- autophagySemantic proximity Read ↗

The Role of Metabolic Remodeling in Macrophage Polarization and Its Effect on Skeletal Muscle Regeneration.Semantic proximity Read ↗

Targeting different phenotypes of macrophages: A potential strategy for natural products to treat inflammatory bone and joint diseases.Semantic proximity Read ↗

4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetesSemantic proximity Read ↗

The Role of Autophagy and Macrophage Polarization in the Process of Chronic Inflammation and RegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.