Article
The physiological phenomenon and regulation of macrophage polarization in diabetic wound.
Molecular biology reports - 1 Nov 2023
Cai Feiyu, Wang Peng, Chen Wenjiao, Zhao Ruomei, Liu Yi
Abstract excerpt
Macrophages play a crucial role in regulating wound healing, as they undergo a transition from the proinflammatory M1 phenotype to the proliferative M2 phenotype, ultimately contributing to a favorable outcome. However, in hyperglycemic and hyper-reactive oxygen species environments, the polarization of macrophages becomes dysregulated, hindering the transition from the inflammatory to proliferative phase and...
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