Article

Notch/NICD/RBP-J Signaling Axis Regulates M1 Polarization of Macrophages Mediated by Advanced Glycation End Products

2021-11-02

Abstract excerpt

<title>Abstract</title> <p>Advanced glycation end products (AGEs) aggregation and macrophages polarization both play essential roles in degenerative bone diseases caused by aging or diabetes, such as senile or diabetic osteoporosis. Here, we aimed to understand the involvement and potential mechanism of AGEs in macrophages polarization and osteoclastogenesis. We found that RAW264.7 macrophages treated with AGEs h...

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Literature Corpus work: 71a1e173-5822-5b83-acac-ec468f38ea44
DOI: 10.21203/rs.3.rs-995474/v1

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