Targeting different phenotypes of macrophages: A potential strategy for natural products to treat inflammatory bone and joint diseases.

Abstract excerpt

BACKGROUND: Macrophages, a key class of immune cells, have a dual role in inflammatory responses, switching between anti-inflammatory M2 and pro-inflammatory M1 subtypes depending on the specific environment. Greater numbers of M1 macrophages correlate with increased production of inflammatory chemicals, decreased osteogenic potential, and eventually bone and joint disorders. Therefore, reversing M1 macrophages...

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• AMP-Activated Protein Kinases
• Arthritis, Rheumatoid
• Biological Products
• Macrophages
• NF-kappa B