Article

The Role of Glycan Structures in Modulating GM-CSF Bioactivity: Insights from Glycoengineering

2026-02-18

Abstract excerpt

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein cytokine with therapeutic potential in cancer and neutropenia treatment. While glycosylation of GM-CSF reduces immunogenicity and enhances serum bioavailability, it can also diminish receptor binding and bioactivity. Based on transcriptomic analysis of human T lymphocytes reported previously, GM-CSF–producing cells exhibit elevated express...

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Literature Corpus work: ed4c1151-f580-5686-9aa7-2279e43a0e0c
DOI: 10.64898/2026.02.17.706267

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