Article

Glycosylated GM-CSF expands B-1b cells and B-1b plasma cells and programs them for immunosuppression

2026-02-04

Abstract excerpt

The myeloid growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF) exhibits paradoxical pro- and anti-inflammatory functions, but the factors determining these divergent outcomes remain unclear. Here, we report that this functional divergence is controlled by its glycosylation. Murine recombinant fully glycosylated GM-CSF (rgGM-CSF) specifically induces immunosuppressive cell types, whereas its re...

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Literature Corpus work: caade24b-5ecd-53df-8bee-50586f0c7ccf
DOI: 10.64898/2026.02.02.703206

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