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Article

Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression.

Cellular oncology (Dordrecht, Netherlands) - 1 Jun 2023

de-Souza-Ferreira Michelle, Ferreira Érika Elias, de-Freitas-Junior Julio Cesar Madureira

Abstract excerpt

BACKGROUND: Changes in protein glycosylation are widely observed in tumor cells. N-glycan branching through adding β1,6-linked N-acetylglucosamine (β1,6-GlcNAc) to an α1,6-linked mannose, which is catalyzed by the N-acetylglucosaminyltransferase V (MGAT5 or GnT-V), is one of the most frequently observed tumor-associated glycan structure formed. Increased levels of this branching structure play a pro-tumoral role...

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Identifiers

PMID: 36689079
DOI: 10.1007/s13402-023-00770-4
PMCID: PMC12974675

Genes

MGAT5

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