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Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies

22 Jun 2023

Abstract excerpt

Over recent decades, therapeutic proteins have had widespread success in treating a myriad of diseases. Glycosylation, a near universal feature of this class of drugs, is a critical quality attribute that significantly influences the physical properties, safety profile and biological activity of therapeutic proteins. Optimizing protein glycosylation, therefore, offers an important avenue to developing more...

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PMID: 37354999
DOI: 10.1016/j.biotechadv.2023.108206

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