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Glycoengineering design options for IgG1 in CHO cells using precise gene editing

26 Mar 2018

Abstract excerpt

Precise gene editing technologies are providing new opportunities to stably engineer host cells for recombinant production of therapeutic glycoproteins with different glycan structures. The glycosylation of recombinant therapeutics has long been a focus for both quality and consistency of products and for optimizing and improving pharmacokinetic properties as well as bioactivity. Structures of glycans on...

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PMID: 29596681
DOI: 10.1093/glycob/cwy022

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