Article

The Molecular Determinants of a Universal Prion Acceptor

2024-03-04

Abstract excerpt

In prion diseases, the species barrier limits the transmission of prions from one species to another. However, cross-species prion transmission is remarkably efficient in bank voles, and this phenomenon can be recapitulated in mice by expression of the bank vole prion protein (BVPrP). The molecular determinants of BVPrP’s ability to function as a universal or near-universal acceptor for prions remain incompletely...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed458de8-1e59-5328-beb9-5cd741d5c2ec
DOI: 10.1101/2024.03.01.582976

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Molecular Determinants of a Universal Prion AcceptorDOI 10.1101/2024.03.01.582976Read

Convergent generation of atypical prions in knock-in mouse models of genetic prion diseaseSemantic proximity Read

A domain responsible for spontaneous conversion of bank vole prion protein.Semantic proximity Read

Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex- dependent onset, early NfL elevation, and universal prion strain permissivenessSemantic proximity Read

Gerstmann-Sträussler-Scheinker disease subtypes efficiently transmit in bank voles as genuine prion diseases.Semantic proximity Read

Different folding mechanisms in prion proteins from mammals with different disease susceptibility observed at the single-molecule levelSemantic proximity Read

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategySemantic proximity Read

Transmissibility of Gerstmann-Sträussler-Scheinker syndrome in rodent models: New insights into the molecular underpinnings of prion infectivity.Semantic proximity Read

The Glycosylation Status of PrP <sup>C</sup> Is a Key Factor in Determining Transmissible Spongiform Encephalopathy Transmission between SpeciesSemantic proximity Read

Isolation of a Defective Prion Mutant from Natural Scrapie.Semantic proximity Read

Gerstmann-Sträussler-Scheinker Disease with F198S Mutation Induces Independent Tau and Prion Protein Pathologies in Bank Voles.Semantic proximity Read

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.Semantic proximity Read

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease modelSemantic proximity Read