Article

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model

2026-03-27

Abstract excerpt

<h4>ABSTRACT</h4> The replacement of a single codon in the human prion gene, causing the substitution of glycine with valine at position 127 (G127V) of the prion protein (PrP), prevents development of prion disease. We set out to explore if prion disease survival extension manifests in mice if the V127 mutant is delivered through a recombinant adeno-associated virus (rAAV) packaged as a self-complementary DNA. Th...

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Identifiers and source

Literature Corpus work: 94449c4d-2586-55ea-a136-f81a922ac36b
DOI: 10.64898/2026.03.27.714700

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