Article
Isolation of a Defective Prion Mutant from Natural Scrapie.
PLoS pathogens - 1 Nov 2016
Vanni Ilaria, Migliore Sergio, Cosseddu Gian Mario, Di Bari Michele Angelo, Pirisinu Laura, D'Agostino Claudia, Riccardi Geraldina, Agrimi Umberto, Nonno Romolo
Abstract excerpt
It is widely known that prion strains can mutate in response to modification of the replication environment and we have recently reported that prion mutations can occur in vitro during amplification of vole-adapted prions by Protein Misfolding Cyclic Amplification on bank vole substrate (bvPMCA). Here we exploited the high efficiency of prion replication by bvPMCA to study the in vitro propagation of natural...
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