Article

Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex- dependent onset, early NfL elevation, and universal prion strain permissiveness

2025-10-18

Abstract excerpt

<title>Abstract</title> <p> Transgenic mice overexpressing bank vole prion protein with the isoleucine 109 polymorphism TgVole(I109)4x develop spontaneous neurodegenerative disease with sex-dependent onset, averaging 170 days in females and 200 days in males at terminal stage. The clinical and pathological features closely resemble Gerstmann-Sträussler-Scheinker syndrome (GSS), with characteristic ataxia, dysmet...

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Literature Corpus work: db76641d-578c-5b8d-a66a-bbba02c51135
DOI: 10.21203/rs.3.rs-7464304/v1

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