Article

Different folding mechanisms in prion proteins from mammals with different disease susceptibility observed at the single-molecule level

2024-08-10

Abstract excerpt

Misfolding of the protein PrP causes prion diseases in mammals. Disease susceptibility varies widely among species, despite PrP sequences differing by only a few amino acids. How these differences alter PrP folding and misfolding remains unclear. We compared the folding dynamics of single PrP molecules from three species with different disease susceptibility: dogs (immune), hamsters (susceptible), and bank voles (...

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Literature Corpus work: 11658615-b086-5b85-a35a-1f4cb49acb0c
DOI: 10.1101/2024.08.09.607387

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