Article

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy

2026-02-18

Abstract excerpt

<h4>ABSTRACT</h4> Prion diseases are fatal neurodegenerative disorders with no approved therapies that halt or reverse disease progression. Given that cellular prion protein (PrP C ) expression is required for prion propagation and neurotoxicity, reducing its expression is a promising therapeutic strategy. However, complete PrP ablation, as seen in knockout models, causes subtle developmental and behavioral abno...

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Literature Corpus work: e96bf3d3-8c66-5775-bfc0-fbf1b2f4c135
DOI: 10.64898/2026.02.17.703887

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