Article

Convergent generation of atypical prions in knock-in mouse models of genetic prion disease

2023-09-27

Abstract excerpt

Most cases of human prion disease arise due to spontaneous misfolding of wild-type or mutant prion protein. Though recapitulating spontaneous prion conversion in animal models has proven challenging, transgenic mice expressing the misfolding-prone bank vole prion protein (BVPrP) recreate certain key aspects of sporadic and genetic prion disease. However, it remains unclear whether spontaneous prion generation can...

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Literature Corpus work: e3bcc43d-f377-56ce-bb1a-350e11b77401
DOI: 10.1101/2023.09.26.559572

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