Article

Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice

2026-02-22

Abstract excerpt

<h4>Aims/hypothesis</h4> Human islet amyloid polypeptide (hIAPP) deposition is a common feature of type-2 diabetes (T2D). Previous studies have demonstrated hIAPP-mediated endothelial cell (EC) dysfunction and inflammation, but little is known about islet microvascular stability or pericyte function in hIAPP-containing islets. This study investigates how islet endothelial cells and pericytes are influenced by hIA...

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Literature Corpus work: ed447f0e-1f06-523a-bc2f-b6fc28100a21
DOI: 10.64898/2026.02.21.707196

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