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Article

Transformation of the microvascular system during multistage tumorigenesis.

International journal of cancer - 20 Feb 2002

Ryschich Eduard, Schmidt Jan, Hämmerling Günter J, Klar Ernst, Ganss Ruth

Abstract excerpt

Simian virus SV40 large T Antigen expression in the islets of Langerhans of transgenic mice results in beta-cell hyperproliferation, onset of new blood vessel formation and the development of highly vascularized solid tumors. Angiogenesis in the RIPTag mouse model, as well as in human cancer, is a hallmark of multistage tumorigenesis and precedes the development of solid tumors. In our study, intravital...

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Identifiers

PMID: 11857345
DOI: 10.1002/ijc.10074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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