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Article

IL-1β-induced pericyte dysfunction with a secretory phenotype exacerbates retinal microenvironment inflammation via Hes1/STAT3 signaling pathway.

International immunopharmacology - 10 Jan 2025

Huang Caoxin, Zhang Xiaofang, Wu Menghua, Yang Chen, Ge Xilin, Chen Wenting, Li Xuejun, Liu Suhuan, Yang Shuyu

Abstract excerpt

Retinal pericytes are mural cells surrounding capillaries to maintain the integrity of blood-retina barrier and regulate vascular behaviors. Pericyte loss has been considered as the hallmark of diabetic retinopathy (DR), which is a major complication of diabetes and the leading cause of blindness in adults. However, the precise function of pericytes in regulating the retinal microenvironment and the underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39612772
DOI: 10.1016/j.intimp.2024.113611

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