Article

PTTG1-Mediated Pericyte Dysfunction Drives Diabetes-Induced Microvascular Dysfunction

2024-12-04

Abstract excerpt

<h4>Background</h4> Pericytes are crucial for the development, stabilization, and functional regulation of microvasculature, especially in the retina. In diabetic retinopathy (DR), early loss of pericytes is a key event that drives microvascular dysfunction. Despite their critical role, the mechanisms underlying the functional heterogeneity of pericytes in DR remain poorly understood, impeding the development of...

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Literature Corpus work: c8d2da5e-817d-5457-9dcc-d2ea7bb96805
DOI: 10.1101/2024.12.02.626502

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