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A Conserved Stress-Inducible Hub Enhancer Governs Natriuretic Peptide Expression and Undergoes Dynamic and Reversible Activation in Human Heart Failure

2025-10-15

Abstract excerpt

<h4>Background</h4> Natriuretic peptides (NPs), encoded by the NPPA and NPPB genes, serve as both diagnostic biomarkers and cardioprotective hormones in heart failure. Their expression is tightly regulated by mechanical load, yet the upstream enhancer mechanisms translating hemodynamic stress into transcriptional activation remain incompletely understood. <h4>Methods</h4> We investigated the Nppa / Nppb sup...

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Literature Corpus work
ed2bbc24-7255-51c7-90d3-e593853c53ac
DOI
10.1101/2025.10.13.682224
Open publication

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A Conserved Stress-Inducible Hub Enhancer Governs Natriuretic Peptide Expression and Undergoes Dynamic and Reversible Activation in Human Heart FailureDOI 10.1101/2025.10.13.682224
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