Article

Linking Chamber-Specific Spatial Chromatin Interactions to Disease Variants and Gene Programs in Human Cardiomyocytes

2024-09-11

Abstract excerpt

<title>Abstract</title> <p>Cell-type specific gene expression programs and response to stimuli are modulated by cis-regulatory elements (CREs). CREs modulate the activity of spatially interacting gene promoters. Heart disease is a major cause of death worldwide. Here, we aim to decode CRE-promoter interactions in atrial and ventricular cardiomyocytes and link them to heart disease and genetic risk factors. Theref...

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Literature Corpus work: 0e050613-25a4-5816-952e-359b6f88dbdb
DOI: 10.21203/rs.3.rs-5039927/v1

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