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Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression

6 Mar 2024

Abstract excerpt

Endothelial cells play crucial roles in physiology and are increasingly recognized as therapeutic targets in cardiovascular disease. Here, we analyzed the regulatory landscape of cardiac endothelial cells by assessing chromatin accessibility, histone modifications, and 3D chromatin organization and confirmed the functional relevance of enhancer-promoter interactions by CRISPRi-mediated enhancer silencing. We used...

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PMID: 38446896
DOI: 10.1126/sciadv.adj5101

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