Article

Linking Chamber-Specific Spatial Chromatin Interactions to Disease Variants and Gene Programs in Human Cardiomyocytes

2024-09-10

Abstract excerpt

<title>Abstract</title> <p> Cell-type specific gene expression programs and response to stimuli are modulated by <italic>cis-</italic> regulatory elements (CREs). CREs modulate the activity of spatially interacting gene promoters. Heart disease is a major cause of death worldwide. Here, we aim to decode CRE-promoter interactions in atrial and ventricular cardiomyocytes and link them to heart disease and geneti...

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Literature Corpus work: c2ad9670-7a81-56de-982d-d81909d1b791
DOI: 10.21203/rs.3.rs-1897221/v2

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